Worldwide, obesity is a growing epidemic and a leading non-communicative disease. Egypt has high levels of obesity, which is causing harm to both individuals and society. This study aimed to collect data on available programs and interventions, to assess gaps and explore assets and challenges to obesity programming in Egypt. The purpose of this article is to examine obesity from an ecological perspective, direct practical work related to obesity to help fill these gaps. Semi-structured interviews were conducted with 25 participants from 22 different organizations, including ministries, governmental, non-governmental, international organizations, and for-profit organizations. Finally, participants provided their personal recommendations for combating obesity in Egypt. The findings from this research showed that there is a lack of nationwide programs and services that tackle obesity; however, there are some minor activities and services that tackle other health issues related to obesity. This information is beneficial to connect programs and build coalitions. Participants related their challenges to mainly contextual and ecological factors and recommended collaboration, partnerships and multi-sectorial programs on a mass scale including national campaigns to get obesity recognized and on the national agenda. Recommendations can help develop prevention strategies that are tailored to the socio-cultural and economic context of Egypt and similar countries.