Research on community organizations suggests there are a variety of factors related to the success of an organization’s mission. This study identifies general facilitators and challenges advocates working against human trafficking experience and the strategies utilized to overcome these barriers. Fifteen individuals who are advocates in the Chicagoland area participated in the study. Qualitative methods using the social ecological theoretical framework show personal, organizational, and system-wide factors impacting advocates. Individual support systems and advocates’ collaborations with other organizations are encouraging factors in their work. Furthermore, advocates feel motivated by trafficked persons’ stories and by the capacity to raise awareness through social media. Challenges advocates face include a lack of time and money, a lack of communication among organizations, and negative cultural attitudes related to trafficking. Results focus on the specific experiences of anti-trafficking advocates and convey strategies to provide quality services to survivors and effectively raise awareness in the general public.