Community-based substance abuse prevention initiatives often rely on the empowerment of community residents. Few studies, however, have examined predictors of empowerment in substance abuse prevention contexts. This study tested a path model that included two environment-related variables (i.e., residents’ awareness of community substance abuse problems and perceived incivilities in their community), two variables representing residents’ perceptions of their community (i.e., sense of community and perceived police responsiveness to drug crime) and citizen participation as predictors of the intrapersonal component of psychological empowerment. The model was found to provide a good fit to the data from a random sample of urban residents (n=283) who participated in an evaluation of a National Institute of Justice community policing initiative in the Southwestern United States. Findings suggest that empowerment-based interventions aimed at preventing substance abuse and its related harmful consequences should incorporate activities that specifically address sense of community and police responsiveness to drug crime. Limitations and directions for future research are discussed.