Early informatics focused primarily on the application of technology and computer science to a specific domain; modern informatics has broadened to encompass human and knowledge dimensions. Application of technology is but one aspect of informatics. Understanding domain members’ issues, priorities, knowledge, abilities, interactions, tasks and work environments is another aspect, and one that directly impacts application success. Involving domain members in the design and development of technology in their domain is a key factor in bridging the gap between technology and science. This user-centered design (UCD) approach in informatics is presented via an ecoinformatics case study in three areas: collaboration, usability, and education and training.