Metabolic Reprogramming and DNA Damage Response in Prostate Cancer: Implication for treatment

Abstract

Dysregulation of metabolism and the DNA damage response are two hallmarks of cancer. With respect to the former, although most cancer types exhibit increased glycolysis (the Warburg effect), this is not the case for prostate cancer. Accordingly, we review the unique metabolic features of prostate cancer, including androgen receptor signaling, glucose metabolism, treatment vulnerabilities, metformin, and combination therapies. With respect to the latter, we review genomic instability in cancer, DNA repair subtypes, the role of Mre11 in DNA double-strand break repair, and the potential regulation of Mre11 by Plk1-mediated phosphorylation.