Partners in Crime: Synergistic Antiapoptotic Effects of HCMV Gene Products in Infected Cells


  • Kaitlyn Sy University of Kansas Edwards Campus



Human cytomegalovirus, HCMV, Latent infection, Immune evasion, Apoptosis, microRNAs, miRNAs, FOXO3a


The means by which human cytomegalovirus (HCMV) evades the immune system has been a hot research topic for the past three decades. While much of the research has focused on viral proteins that interfere with the host’s immune response, recent investigations suggest that proteins are not the only culprits. New findings by Hancock et al. indicate that HCMV-encoded microRNAs (miRNAs) work alongside viral proteins to produce synergistic antiapoptotic effects, shedding light on the mechanisms by which HCMV establishes latent infection in host cells.


Griffiths, P. & Reeves, M. Pathogenesis of human cytomegalovirus in the immunocompromised host. Nature Reviews Microbiology 19, 759–773 (2021). doi:10.1038/s41579-021-00582-z

Hancock, M. H. et al. Human cytomegalovirus UL7, miR-US5-1, and miR-UL112-3P inactivation of FOXO3A protects CD34+ hematopoietic progenitor cells from apoptosis. mSphere 6, (2021). doi:10.1128/mSphere.00986-20

Ahn, K. et al. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proceedings of the National Academy of Sciences 93, 10990–10995 (1996). doi:10.1073/pnas.93.20.10990

Wiertz, E. J. H. J. et al. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84, 769–779 (1996). doi:10.1016/S0092-8674(00)81054-5

Reyburn, H. T. et al. The class I MHC homologue of human cytomegalovirus inhibits attack by Natural Killer Cells. Nature 386, 514–517 (1997). doi:10.1038/386514a0

Arnoult, D. et al. Cytomegalovirus cell death suppressor vmia blocks bax- but not bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proceedings of the National Academy of Sciences 101, 7988–7993 (2004). doi:10.1038/386514a0

Terhune, S. et al. Human cytomegalovirus UL38 protein blocks apoptosis. Journal of Virology 81, 3109–3123 (2007). doi:10.1128/JVI.02124-06

Dabrowska, A., Kim, N. & Aldovini, A. TAT-induced FOXO3A is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. The Journal of Immunology 181, 8460–8477 (2008). doi:10.4049/jimmunol.181.12.8460

Crawford, L. B. et al. Human cytomegalovirus encodes a novel FLT3 receptor ligand necessary for hematopoietic cell differentiation and viral reactivation. mBio 9, (2018). doi:10.1073/pnas.0401897101

Ramalingam, D., Kieffer-Kwon, P. & Ziegelbauer, J. M. Emerging themes from EBV and KSHV microrna targets. Viruses 4, 1687–1710 (2012). doi:10.3390/v4091687




How to Cite

Sy, K. (2024). Partners in Crime: Synergistic Antiapoptotic Effects of HCMV Gene Products in Infected Cells. Midwestern Journal of Undergraduate Sciences, 2(1).