Chikungunya virus might be resistant to the complement system

Authors

  • Guenaele Raphael University of Kansas/ senior in biotech

DOI:

https://doi.org/10.17161/mjusc.v2i1.20308

Keywords:

virus, Chikungunya, HCMV, CHIKV

References

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Meylan, E. et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167–1172 (2005).

Legarda, D., Klein-Patel, M. E., Yim, S., Yuk, M. H. & Diamond, G. Suppression of NF-κB-mediated β-defensin gene expression in the mammalian airway by the Bordetella type III secretion system. Cell. Microbiol. 7, 489–497 (2005).

Caglioti, C. et al. Chikungunya virus infection: an overview. New Microbiol. 36, 211–227 (2013).

Ross, R. W. The Newala epidemic. III. The virus: isolation, pathogenic properties and relationship to the epidemic. J. Hyg. (Lond.) 54, 177–191 (1956).

Ng, L. F. P. et al. IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity. PLoS ONE 4, e4261 (2009).

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Fros, J. J. et al. Chikungunya Virus Nonstructural Protein 2 Inhibits Type I/II Interferon-Stimulated JAK-STAT Signaling. J. Virol. 84, 10877–10887 (2010).

Bae, S., Lee, J. Y. & Myoung, J. Chikungunya Virus-Encoded nsP2, E2 and E1 Strongly Antagonize the Interferon-β Signaling Pathway. 29, 1852–1859 (2019).

Nag, J. et al. A Factor I-Like Activity Associated with Chikungunya Virus Contributes to Its Resistance to the Human Complement System. J. Virol. 94, e02062-19 (2020).

Charles A Janeway, J., Travers, P., Walport, M. & Shlomchik, M. J. The complement system and innate immunity. in Immunobiology: The Immune System in Health and Disease. 5th edition (Garland Science, 2001).

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Published

2024-02-15

How to Cite

Raphael, G. (2024). Chikungunya virus might be resistant to the complement system. Midwestern Journal of Undergraduate Sciences, 2(1), 7-8. https://doi.org/10.17161/mjusc.v2i1.20308