Post-Biopsy Pneumothorax Incidence in Patients Treated with Biosentry Plug Device


  • Hythem Abouodah
  • Gregg Werner, M.D.
  • Thomas M. Fahrbach, M.D.
  • Cameron Fox, Ph.D.
  • Jared Mazurek
  • Jeremy Lott, M.D.
  • Carissa N. Walter, MPH KUMC
  • Lauren Clark, M.S.
  • Brandon Custer, M.D.



Biosentry Plug, Pneumothorax, Chest Tube, Thoracostomy, Lung Biopsy


Introduction: This study aimed to determine if Biosentry Plug Device (BP), a prophylactic sealant used to prevent pneumothorax after lung biopsies, reduced post-lung biopsy pneumothorax rates and other complications compared to no device utilization.

Methods: This single institution, retrospective cohort study included patients who received a lung biopsy in the department of interventional radiology from May 1, 2015 to August 31, 2017. Data such as sex, race, ethnicity, COPD status, degree of lung bullae if present, smoking status, and use of BP were recorded. Decisions to use BP were based on operator preference. A chi squared analysis was used with a p value <0.05 considered significant.

Results: The study included 521 patients who underwent a lung biopsy during the study timeframe. Of these, 74 (14.2%) received the BP device, while 447 (85.8%) did not. One-hundred ninety (36.4%) had a pneumothorax within 1 month of the lung biopsy. Of the total 190 that experienced pneumothorax, 36.7% of non-BP biopsies resulted in pneumothorax, while 35.1% of BP biopsies resulted in pneumothorax, p-value = 0.7970, degrees of freedom = 1.

Conclusions: These findings indicate that BP may not reduce pneumothorax incidence nor limit the severity of complications in patients.






Original Research