Microbes helping microbes

Evidence for gut microbiota establishing conditions permissive to pulmonary infection with M. Tuberculosis

Authors

  • Olive Njoroge KU Biotechnology student
  • Dr. Jack Treml University of Kansas

DOI:

https://doi.org/10.17161/mjusc.v3i1.22408

Keywords:

gut microbiota , tuberculosis, gut-lung axis, immunology, MicroRNA

Abstract

MicroRNAs, small non-coding RNAs that regulate gene expression post-transcriptionally, have emerged as key players in immune regulation and disease pathogenesis. Among these, miR-21 is one of the most highly expressed miRNAs in various tissues and has been implicated in modulating numerous inflammatory responses and immune functions. While the impact of miRNAs on bacterial pathogen-host interactions has been extensively studied, our understanding of their role in gastrointestinal (GI) tract immunity, particularly in the context of Tuberculosis (TB), remains limited.

Author Biography

  • Dr. Jack Treml, University of Kansas

    Dr. Jack Treml is the Assistant Director and Associate Professor of Practice of Biotechnology at the University of Kansas.

References

Zhang, T., Yang, Z., Kusumanchi, P., Han, S. & Liangpunsakul, S. Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases. Front. Med. 7, 7 (2020).

Dumas, A., Bernard, L., Poquet, Y., Lugo-Villarino, G. & Neyrolles, O. The role of the lung microbiota and the gut-lung axis in respiratory

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Bradley, C. P. et al. Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing

Dual TCRs. Cell Host Microbe 22, 697-704. e4 (2017).

Yang, F. et al. MiR-21 Is Remotely Governed by the Commensal Bacteria and Impairs Anti-TB Immunity by Down-Regulating IFN-γ.

Front. Microbiol. 11, 512581 (2021).

Dheda, K. et al. Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis. Lancet Respir. Med. 2, 321–338 (2014).

Maartens, G. & Wilkinson, R. J. Tuberculosis. Lancet Lond. Engl. 370, 2030–2043 (2007).

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Published

2024-09-17

Issue

Vol. 3 No. 1 (2024): Midwestern Journal of Undergraduate Sciences: Symbiosis

Section

Reviews

License

Copyright (c) 2024 Olive Njoroge, Dr. Jack Treml

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license. 

How to Cite

Njoroge, O., & Treml, J. (2024). Microbes helping microbes: Evidence for gut microbiota establishing conditions permissive to pulmonary infection with M. Tuberculosis. Midwestern Journal of Undergraduate Sciences, 3(1), 13. https://doi.org/10.17161/mjusc.v3i1.22408