Microbes helping microbes

Evidence for gut microbiota establishing conditions permissive to pulmonary infection with M. Tuberculosis

Autores

  • Olive Njoroge KU Biotechnology student
  • Jack Treml University of Kansas

DOI:

https://doi.org/10.17161/mjusc.v3i1.22408

Palavras-chave:

gut microbiota , tuberculosis, gut-lung axis, immunology, MicroRNA

Resumo

MicroRNAs, small non-coding RNAs that regulate gene expression post-transcriptionally, have emerged as key players in immune regulation and disease pathogenesis. Among these, miR-21 is one of the most highly expressed miRNAs in various tissues and has been implicated in modulating numerous inflammatory responses and immune functions. While the impact of miRNAs on bacterial pathogen-host interactions has been extensively studied, our understanding of their role in gastrointestinal (GI) tract immunity, particularly in the context of Tuberculosis (TB), remains limited.

Biografia do Autor

  • Jack Treml, University of Kansas

    Dr. Jack Treml is the Assistant Director and Associate Professor of Practice of Biotechnology at the University of Kansas.

Referências

Zhang, T., Yang, Z., Kusumanchi, P., Han, S. & Liangpunsakul, S. Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases. Front. Med. 7, 7 (2020).

Dumas, A., Bernard, L., Poquet, Y., Lugo-Villarino, G. & Neyrolles, O. The role of the lung microbiota and the gut-lung axis in respiratory

infectious diseases. Cell. Microbiol. 20, e12966 (2018).

Bradley, C. P. et al. Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing

Dual TCRs. Cell Host Microbe 22, 697-704. e4 (2017).

Yang, F. et al. MiR-21 Is Remotely Governed by the Commensal Bacteria and Impairs Anti-TB Immunity by Down-Regulating IFN-γ.

Front. Microbiol. 11, 512581 (2021).

Dheda, K. et al. Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis. Lancet Respir. Med. 2, 321–338 (2014).

Maartens, G. & Wilkinson, R. J. Tuberculosis. Lancet Lond. Engl. 370, 2030–2043 (2007).

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Publicado

2024-09-17

Edição

v. 3 n. 1 (2024): Midwestern Journal of Undergraduate Sciences: Symbiosis

Seção

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Licença

Copyright (c) 2024 Olive Njoroge, Dr. Jack Treml

Creative Commons License

Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.

© The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license. 

Como Citar

Njoroge, O., & Treml, J. (2024). Microbes helping microbes: Evidence for gut microbiota establishing conditions permissive to pulmonary infection with M. Tuberculosis. Midwestern Journal of Undergraduate Sciences, 3(1), 13. https://doi.org/10.17161/mjusc.v3i1.22408