The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses
DOI:
https://doi.org/10.17161/mjusc.v3i1.22348Palabras clave:
ELMO1, NOD2, inflammatory bowel diseases , Crohn's diseaseResumen
Microbial sensors are integral to maintaining cellular homeostasis and orchestrating immune responses within the intestinal environment. The mechanisms contributing to differential immune responses and their link to inflammatory bowel diseases (IBD) are not yet fully understood. IBD is an umbrella term used to describe disorders that cause chronic inflammation of the gastrointestinal tract. This review explores The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses during enteric infections of AIEC-LF82 and Salmonella published in the February 2023 Virulence Journal by Aditi Sharma et al.
Referencias
What is IBD? | Crohn’s & Colitis Foundation. https://www.crohnscolitisfoundation.org/patientsandcaregivers/ what-is-ibd.
Billmann-Born, S. et al. Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn’s disease-associated NOD2 variant L1007fsinsC. J. Immunol. Baltim. Md 1950 186, 4027–4038 (2011).
Ramanan, D., Tang, M. S., Bowcutt, R., Loke, P. & Cadwell, K. Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity 41, 311–324 (2014).
Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411, 603–606 (2001).
Girardin, S. E., Hugot, J. P. & Sansonetti, P. J. Lessons from Nod2 studies: towards a link between Crohn’s disease and bacterial sensing. Trends Immunol. 24, 652–658 (2003).
Dickson, I. Impaired bacterial clearance in IBD. Nat. Rev. Gastroenterol. Hepatol. 13, 251–251 (2016).
Constant, D. A., Nice, T. J. & Rauch, I. Innate immune sensing by epithelial barriers. Curr. Opin. Immunol. 73, 1–8 (2021).
Komander, D. et al. An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol. Biol. Cell 19, 4837–4851 (2008).
Sharma, A. et al. The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses. Virulence 14, 2171690 (2023).
Inohara, N. et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn’s disease. J. Biol. Chem. 278, 5509–5512 (2003).
Girardin, S. E. et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869–8872 (2003).
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Derechos de autor 2024 bridget ruhme, Jack Treml
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