The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses

Auteurs

  • bridget ruhme University of Kansas
  • Jack Treml University of Kansas

DOI :

https://doi.org/10.17161/mjusc.v3i1.22348

Mots-clés :

ELMO1, NOD2, inflammatory bowel diseases , Crohn's disease

Résumé

Microbial sensors are integral to maintaining cellular homeostasis and orchestrating immune responses within the intestinal environment. The mechanisms contributing to differential immune responses and their link to inflammatory bowel diseases (IBD) are not yet fully understood. IBD is an umbrella term used to describe disorders that cause chronic inflammation of the gastrointestinal tract. This review explores The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses during enteric infections of AIEC-LF82 and Salmonella published in the February 2023 Virulence Journal by Aditi Sharma et al.

Références

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Komander, D. et al. An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol. Biol. Cell 19, 4837–4851 (2008).

Sharma, A. et al. The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses. Virulence 14, 2171690 (2023).

Inohara, N. et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn’s disease. J. Biol. Chem. 278, 5509–5512 (2003).

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Publiée

2024-09-17

Comment citer

ruhme, bridget, & Treml, J. (2024). The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses. Midwestern Journal of Undergraduate Sciences, 3(1), 11-12. https://doi.org/10.17161/mjusc.v3i1.22348