Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course

Auteurs

  • Sireen Aburaide Augsburg University
  • Pader Xiong Augsburg University
  • Daniel Wolfson Augsburg University
  • Tashi Wangmo Augsburg University
  • Anthony Vassallo Augsburg University
  • DJ Smith Augsburg University
  • Madeline Shaw Augsburg University
  • Luis Millan Augsburg University
  • Samantha Meyer Augsburg University
  • Bobby Lee Augsburg University
  • Divine Katasi Augsburg University
  • Evelyn Juen Augsburg University
  • Allison Hookam Augsburg University
  • Ahmed Elewa Miami University
  • Yoskar Deleon Augsburg University
  • Mason Chamberlain Augsburg University
  • Ahmed Suad Augsburg University
  • Lian Yaeger Augsburg University

DOI :

https://doi.org/10.17161/mjusc.v4i1.24548

Mots-clés :

C.. elegans, nematode, developmental, microbiology

Résumé

Caenorhabditis elegans is a widely used model organism in biomedical research due to its genetic tractability, short life cycle, and conservation of many developmental processes with humans. In this study, undergraduate students conducted nine independent experiments during a Developmental Biology course to model human phenotypes using C. elegans. Each group selected a human phenotype of interest, identified a gene associated with the phenotype, and then determined the orthologous or homologous gene in C. elegans. By obtaining mutants and designing phenotypic assays, students investigated the extent to which the worm models could recapitulate aspects of the human condition. This collective work highlights both the potential and limitations of C. elegans as a model for human phenotypic variation and disease and demonstrates the value of undergraduate inquiry as a catalyst for scientific engagement and research-based learning.

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Publiée

2025-09-22

Numéro

Vol. 4 No 1 (2025): Midwestern Journal of Undergraduate Sciences: Armoring the Immune System

Rubrique

The CURE Report

Licence

(c) Copyright Sireen Aburaide, Pader Xiong, Daniel Wolfson, Tashi Wangmo, Anthony Vassallo, DJ Smith, Madeline Shaw, Luis Millan, Samantha Meyer, Bobby Lee, Divine Katasi, Evelyn Juen, Allison Hookam, Ahmed Elewa, Yoskar Deleon, Mason Chamberlain, Ahmed Suad, Lian Yaeger 2025

Creative Commons License

Ce travail est disponible sous licence Creative Commons Attribution - Pas d’Utilisation Commerciale 4.0 International.

© The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license. 

Comment citer

Aburaide, S., Xiong, P., Wolfson, D., Wangmo, T., Vassallo, A., Smith, D., Shaw, M., Millan, L., Meyer, S., Lee, B., Katasi, D., Juen, E., Hookam, A., Elewa, A., Deleon, Y., Chamberlain, M., Suad, A., & Yaeger, L. (2025). Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course. Midwestern Journal of Undergraduate Sciences, 4(1), 38-47. https://doi.org/10.17161/mjusc.v4i1.24548