Myasthenia Gravis Exacerbation with Shingrix Vaccine
DOI:
https://doi.org/10.17161/rrnmf.v1i4.13749Keywords:
Shingrix, Myasthenia exacerbation, Auto-immunity, Adjuvants.Abstract
Shingrix is a non-live recombinant vaccine approved to prevent herpes zoster infection, and its efficacy, and safety are well studied. The risk of vaccine-related complications in myasthenia symptoms is higher with live vaccines. However, Shingrix, a non-live vaccine causing exacerbation of the myasthenia symptoms, has not been reported to date. Herein, we present a case of stable myasthenia gravis that got exacerbated after a single dose of Shingrix vaccination.
Metrics
Metrics Loading ...
Downloads
Download data is not yet available.
References
1. Cunningham A.L. et al. (2016) Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older. N Engl J Med. 15;375(11):1019-32. DOI: 10.1056/NEJMoa1603800.
2. Yawn BP, Saddier P, Wollan PC, St Sauver JL, Kurland MJ, Sy LS. (2007) A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction, Mayo Clin Proc, vol. 82(pg. 1341-9) DOI: 10.4065/82.11.1341.
3. Hesse E M., Shimbakuro T T. et al. (2019) Postlicensure Safety Surveillance of Recombinant Zoster Vaccine (Shingrix) — United States, October 2017–June 2018. MMWR Morb Mortal Wkly Rep1;68(4):91-94. DOI: 10.15585/mmwr.mm6804a4.
4. F. Maltz, B. Filder. (2019) Shingrix: A New Herpes Zoster Vaccine. P.T. 44(7): 406-409,433.
5. Vered Molina, Yehuda Shoenfeld. (2005) Infections, Vaccines, and Other Environmental triggers of Auto-immunity. Autoimmunity. 38(3):235-45. DOI: 10.1080/08916930500050277.
6. E. Israeli, N. Agmon-Levin, M. Blank, Y.Shoenfeld. (2009) Adjuvants and autoimmunity, vol. 18pp. 1217-1225 DOI: 10.1177/0961203309345724.
7. Chung, J.Y., Lee, S.J., Shin, B. et al. (2018) Myasthenia gravis following human papillomavirus vaccination: a case report. BMC Neurol 18, 222. https://doi.org/10.1186/s12883-018-1233-y
8. Stübgen JP. (2010) Neuromuscular disorders associated with hepatitis B vaccination. J Neurol Sci. 292(1–2):1–4. DOI: 10.1016/j.jns.2010.02.016.
9. Biron P., Montpetit P., Infante-Rivard C., and Léry L. (1988) Myasthenia gravis after general anesthesia and hepatitis B vaccine. Arch Int Med. 148: pp. 2685 DOI: 10.1001/archinte.1988.00380120123025.
10. Louzir B, Othmani S, Battikh R, Ben Abdelhafidh N, Bahri M, Taalouche L, et al. (2003) Myasthenia after hepatitis B vaccination. Therapie. 58(4):378–9. DOI: https://doi.org/10.2515/therapie:2003059.
2. Yawn BP, Saddier P, Wollan PC, St Sauver JL, Kurland MJ, Sy LS. (2007) A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction, Mayo Clin Proc, vol. 82(pg. 1341-9) DOI: 10.4065/82.11.1341.
3. Hesse E M., Shimbakuro T T. et al. (2019) Postlicensure Safety Surveillance of Recombinant Zoster Vaccine (Shingrix) — United States, October 2017–June 2018. MMWR Morb Mortal Wkly Rep1;68(4):91-94. DOI: 10.15585/mmwr.mm6804a4.
4. F. Maltz, B. Filder. (2019) Shingrix: A New Herpes Zoster Vaccine. P.T. 44(7): 406-409,433.
5. Vered Molina, Yehuda Shoenfeld. (2005) Infections, Vaccines, and Other Environmental triggers of Auto-immunity. Autoimmunity. 38(3):235-45. DOI: 10.1080/08916930500050277.
6. E. Israeli, N. Agmon-Levin, M. Blank, Y.Shoenfeld. (2009) Adjuvants and autoimmunity, vol. 18pp. 1217-1225 DOI: 10.1177/0961203309345724.
7. Chung, J.Y., Lee, S.J., Shin, B. et al. (2018) Myasthenia gravis following human papillomavirus vaccination: a case report. BMC Neurol 18, 222. https://doi.org/10.1186/s12883-018-1233-y
8. Stübgen JP. (2010) Neuromuscular disorders associated with hepatitis B vaccination. J Neurol Sci. 292(1–2):1–4. DOI: 10.1016/j.jns.2010.02.016.
9. Biron P., Montpetit P., Infante-Rivard C., and Léry L. (1988) Myasthenia gravis after general anesthesia and hepatitis B vaccine. Arch Int Med. 148: pp. 2685 DOI: 10.1001/archinte.1988.00380120123025.
10. Louzir B, Othmani S, Battikh R, Ben Abdelhafidh N, Bahri M, Taalouche L, et al. (2003) Myasthenia after hepatitis B vaccination. Therapie. 58(4):378–9. DOI: https://doi.org/10.2515/therapie:2003059.
Downloads
Published
2020-09-21
Issue
Section
Clinic Stuff (Case Reports)
License
Copyright (c) 2020 Lakshmi Digala, Raghav Govindarjan
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
Digala, L., & Govindarjan, R. (2020). Myasthenia Gravis Exacerbation with Shingrix Vaccine. RRNMF Neuromuscular Journal, 1(4), 33-34. https://doi.org/10.17161/rrnmf.v1i4.13749
