Covid-19 Re-infection vs Prolonged Viral Shedding
DOI:
https://doi.org/10.17161/rrnmf.v2i2.15057Abstract
Since December 2019, COVID 19 pandemic has devastated communities across the world. As number of patients recovered from COVID 19 continue to rise, question of acquired immunity versus chances of re-infection becomes critical to understand the future spread of infection. Here, we present a case of a patient previously recovered from COVID-19, develops new symptoms concerning for possible re-infection with positive reverse transcriptase-polymerase chain reaction (RT-PCR) after few months of initial infection.
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- Retrieved from Archived: WHO Timeline - COVID-19
- Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017
- Retrieved from Duration of Isolation and Precautions for Adults with COVID-19 | CDC
- Duggan NM, Ludy SM, Shannon BC, Reisner AT, Wilcox SR. Is novel coronavirus 2019 reinfection possible? Interpreting dynamic SARS-CoV-2 test results. Am J Emerg Med. 2021;39:256.e1-256.e3. doi:10.1016/j.ajem.2020.06.079
- Chen D, Xu W, Lei Z, et al. Recurrence of positive SARS-CoV-2 RNA in COVID-19: A case report. Int J Infect Dis. 2020;93:297-299. doi:10.1016/j.ijid.2020.03.003
- Xiao AT, Tong YX, Gao C, Zhu L, Zhang YJ, Zhang S. Dynamic profile of RT-PCR findings from 301 COVID-19 patients in Wuhan, China: A descriptive study. J Clin Virol. 2020;127:104346. doi:10.1016/j.jcv.2020.104346
- Lan L, Xu D, Ye G, et al. Positive RT-PCR Test Results in Patients Recovered From COVID-19. JAMA. 2020;323(15):1502-1503. doi:10.1001/jama.2020.2783
- Paz-Bailey G, Rosenberg ES, Sharp TM. Persistence of Zika Virus in Body Fluids - Final Report. N Engl J Med. 2019;380(2):198-199. doi:10.1056/NEJMc1814416
- Oh MD, Park WB, Choe PG, Choi SJ, Kim JI, Chae J, Park SS, Kim EC, Oh HS, Kim EJ, Nam EY, Na SH, Kim DK, Lee SM, Song KH, Bang JH, Kim ES, Kim HB, Park SW, Kim NJ. Viral Load Kinetics of MERS Coronavirus Infection. N Engl J Med. 2016 Sep 29;375(13):1303-5. doi: 10.1056/NEJMc1511695. PMID: 27682053.
- Li J, Zhang L, Liu B, Song D. Case Report: Viral Shedding for 60 Days in a Woman with COVID-19. Am J Trop Med Hyg. 2020;102(6):1210-1213. doi:10.4269/ajtmh.20-0275
- Retrieved from website: Symptoms of Coronavirus | CDC
- Valette X, du Cheyron D, Goursaud S. Mediastinal lymphadenopathy in patients with severe COVID-19. Lancet Infect Dis. 2020;20(11):1230. doi:10.1016/S1473-3099(20)30310-8
- Distinguin L, Ammar A, Lechien JR, Chetrit A, Idrissi YC, Circiu M, Saussez S, Berradja N, Edjlali M, Carlier R, Hans S. MRI of Patients Infected With COVID-19 Revealed Cervical Lymphadenopathy. Ear Nose Throat J. 2021 Jan;100(1):26-28. doi: 10.1177/0145561320940117.
- Harvey RA, Rassen JA, Kabelac CA, et al. Association of SARS-CoV-2 Seropositive Antibody Test with Risk of Future Infection. JAMA Intern Med. Published online February 24, 2021. doi:10.1001/jamainternmed.2021.0366
- Sheila F. Lumley, B.M., B.Ch., Denise O’Donnell, B.Sc., Nicole E. Stoesser, M.B., B.S., D.Phil., Philippa C. Matthews, F.R.C.P., D.Phil., Alison Howarth, Ph.D., Stephanie B. Hatch, Ph.D., Brian D. Marsden, D.Phil., Stuart Cox, Tim James, Ph.D., Fiona Warren, B.Sc., Liam J. Peck, D.Phil., Thomas G. Ritter, B.A., et al., Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers. 10.1056/NEJMoa2034545, doi: 10.1056/NEJMoa2034545Andrew G. Letizia, Yongchao Ge, Sindhu Vangeti, Carl Goforth, Dawn L Weir, Natalia A. Kuzmina, Hua Wei Chen, Dan Ewing, Alessandra Soares-Schanoski, Mary-Catherine George, William D. Graham, Franca Jones, Preeti Bharaj, Rhonda A. Lizewski, Stephen A. Lizewski, Jan Marayag, Nada Marjanovic, Clare Miller, Sagie Mofsowitz, Venugopalan D. Nair, Edgar Nunez, Danielle M. Parent, Chad K. Porter, Ernesto Santa Ana, Megan Schilling, Daniel Stadlbauer, Victor Sugiharto, Michael Termini, Peifang Sun, Russell. P. Tracy, Florian Krammer, Alexander Bukreyev, Irene Ramos, Stuart C. Sealfon SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study. medRxiv 2021.01.26.21250535; doi: https://doi.org/10.1101/2021.01.26.21250535
- C. H. Hansen et al. Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study. The Lancet. Published online March 17, 2021. doi: 10.1016/S0140-6736(21)00575-4.
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Copyright (c) 2021 Richard J. Barohn, Mary Hindle, Lauren Peck, Syed H. Naqvi
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
