Timing of Decremental Response During Repetitive Nerve Stimulation in Myasthenia Gravis

Authors

  • Gloria Ortiz-Guerrero MD
  • Mazen M. Dimachkie MD University of Kansas Medical Center
  • Mamatha Pasnoor MD
  • Laura Herbelin BS
  • Omar Jawdat MD
  • Melanie Glenn MD
  • Jeffrey Statland MD
  • Duaa Jabari MD
  • Constantine Farmakidis MD
  • Richard J. Barohn MD

DOI:

https://doi.org/10.17161/rrnmf.v3i1.15216

Abstract

Background: A decrement >10% detected during repetitive nerve stimulation (RNS) is supportive of considering a diagnosis of myasthenia gravis (MG). Several studies have found that most of this decrement is seen between 4 to 6 min post-exercise. However, there are not available studies analyzing if shorter timing would be sufficient.  

Objective: The objective of this study was to evaluate if RNS up to 2 min post-exercise is sufficient to detect a decrement response >10%.

Methods: We performed a retrospective chart review study of patients referred to our neuromuscular clinic at The University of Kansas Medical Center with symptoms suggestive of MG from 2013 to 2017.

Results: A total of 76 patients with MG and 100 controls were identified.  A significant decrement was detected in 95% of MG patients with abnormal RNS within 2 minutes post-exercise.

Conclusion: RNS up to 2 min post-exercise might be sufficient to detect a significant decrement in MG patients. 

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Published

2022-03-11

Issue

Section

New Discoveries and Original Research

How to Cite

Ortiz Guerrero, G., Heim, A., Pasnoor, M., Herbelin, L., Jawdat, O., Glenn, M., Statland, J., Jabari, D., Farmakidis, C., & Barohn, R. (2022). Timing of Decremental Response During Repetitive Nerve Stimulation in Myasthenia Gravis. RRNMF Neuromuscular Journal, 3(1), 8-12. https://doi.org/10.17161/rrnmf.v3i1.15216