The Correlation Between Static Fatigue Testing and the Quantitative Myasthenia Gravis Score and Activities of Daily Living Profile

Authors

  • Navdeep Lail, MD Dept. of Neurology, Univ. at Buffalo Jacobs School of Medicine and Biomedical Sciences, SUNY
  • Gil Wolfe, MD Dept. of Neurology, Univ. at Buffalo/SUNY
  • Laura Herbelin, BS Dept. of Neurology, Univ. of Texas Southwestern Medical Center
  • Sharon Nations, MD Dept. of Neurology, Univ. of Texas Southwestern Medical Center
  • Barbara Foster, PhD
  • Nicholas Silvestri, MD
  • Richard J. Barohn, MD University of Missouri

DOI:

https://doi.org/10.17161/rrnmf.v2i5.15440

Keywords:

myasthenia gravis, fatigue, disease outcomes

Abstract

Fatigue is a common symptom in myasthenia gravis (MG), but both objective and subjective measures of fatigue are poorly studied in the disease.  We conducted a pilot study of static fatigue testing (SFT) in a group of MG patients, using an isometric quantified muscle analysis computer system.  Results from sustained isometric contraction of 5 muscle groups in 77 patients were correlated to the Quantitative MG Score (QMG) and the Activities of Daily Living Profile (MG-ADL), two commonly used outcome measures.  Pearson correlation coefficients for the SFT were highest (0.33) for hand grip for both the QMG and MG-ADL.  Correlations were quite poor for the proximal muscle groups and ankle dorsiflexion.  More work is needed to develop objective and subjective measures of fatigue in MG.   

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References

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Published

2021-12-20

Issue

Section

New Discoveries/New Stuff (Original Research)