The Correlation Between Static Fatigue Testing and the Quantitative Myasthenia Gravis Score and Activities of Daily Living Profile

Authors

  • Navdeep Lail, MD Dept. of Neurology, Univ. at Buffalo Jacobs School of Medicine and Biomedical Sciences, SUNY
  • Gil Wolfe, MD Dept. of Neurology, Univ. at Buffalo/SUNY
  • Laura Herbelin, BS Dept. of Neurology, Univ. of Texas Southwestern Medical Center
  • Sharon Nations, MD Dept. of Neurology, Univ. of Texas Southwestern Medical Center
  • Barbara Foster, PhD
  • Nicholas Silvestri, MD
  • Richard J. Barohn, MD University of Missouri

DOI:

https://doi.org/10.17161/rrnmf.v2i5.15440

Keywords:

myasthenia gravis, fatigue, disease outcomes

Abstract

Fatigue is a common symptom in myasthenia gravis (MG), but both objective and subjective measures of fatigue are poorly studied in the disease.  We conducted a pilot study of static fatigue testing (SFT) in a group of MG patients, using an isometric quantified muscle analysis computer system.  Results from sustained isometric contraction of 5 muscle groups in 77 patients were correlated to the Quantitative MG Score (QMG) and the Activities of Daily Living Profile (MG-ADL), two commonly used outcome measures.  Pearson correlation coefficients for the SFT were highest (0.33) for hand grip for both the QMG and MG-ADL.  Correlations were quite poor for the proximal muscle groups and ankle dorsiflexion.  More work is needed to develop objective and subjective measures of fatigue in MG.   

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References

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Published

2021-12-20

Issue

Vol. 2 No. 5 (2021)

Section

New Discoveries and Original Research

License

Copyright (c) 2021 Navdeep Lail, Gil Wolfe, Laura Herbelin, Sharon Nations, Barbara Foster, Nicholas Silvestri, Richard Barohn

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Lail, N., Wolfe, G., Herbelin, L. ., Nations, S. ., Foster, B., Silvestri, N., & Barohn, R. (2021). The Correlation Between Static Fatigue Testing and the Quantitative Myasthenia Gravis Score and Activities of Daily Living Profile. RRNMF Neuromuscular Journal, 2(5), 50-52. https://doi.org/10.17161/rrnmf.v2i5.15440