Exercise Training for autoimmune myasthenia gravis: A review of safety and effectiveness based on existing literature
Keywords:safety, effectiveness, exercise training, autoimmune myasthenia gravis
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Verschuuren JJ, Palace J, Murai H, Tannemaat MR, Kaminski HJ, Bril V. Advances and ongoing research in the treatment of autoimmune neuromuscular junction disorders. Lancet Neurol. 2022;21(2):189-202.
Grob D, Brunner N, Namba T, Pagala M. Lifetime course of myasthenia gravis. Muscle & nerve. 2008;37(2):141-149.
Lehnerer S, Jacobi J, Schilling R, et al. Burden of disease in myasthenia gravis: taking the patient's perspective. Journal of neurology. 2022;269(6):3050-3063.
Jackson K, Parthan A, Lauher-Charest M, Broderick L, Law N, Barnett C. Understanding the symptom burden and impact of myasthenia gravis from the patient's perspective: A qualitative study. Neurol. Ther. 2022.
Sharshar T, Porcher R, Demeret S, et al. Comparison of corticosteroid tapering regimens in myasthenia gravis: A randomized clinical trial. JAMA neurology. 2021;78(4):426-433.
Devlin I, Williams KL, Shrubsole K. Fragmented care and missed opportunities: the experiences of adults with myasthenia gravis in accessing and receiving allied health care in Australia. Disability and rehabilitation. 2022:1-9.
Gamborg M, Hvid LG, Dalgas U, Langeskov-Christensen M. Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis. Acta. Neurol. Scand. 2022;145(5):504-528.
Dalgas U, Langeskov-Christensen M, Stenager E, Riemenschneider M, Hvid LG. Exercise as medicine in multiple sclerosis-time for a paradigm shift: Preventive, symptomatic, and disease-modifying aspects and perspectives. Current neurology and neuroscience reports. 2019;19(11):88.
Weng Q, Goh SL, Wu J, et al. Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials. British journal of sports medicine. 2023.
Langeskov-Christensen M, Hvid LG, Jensen HB, et al. Efficacy of high-intensity aerobic exercise on common multiple sclerosis symptoms. Acta. Neurol. Scand. 2022;145(2):229-238.
Stubbs B, Vancampfort D, Rosenbaum S, et al. An examination of the anxiolytic effects of exercise for people with anxiety and stress-related disorders: A meta-analysis. Psychiatry research. 2017;249:102-108.
Schuch FB, Vancampfort D, Richards J, Rosenbaum S, Ward PB, Stubbs B. Exercise as a treatment for depression: A meta-analysis adjusting for publication bias. Journal of psychiatric research. 2016;77:42-51.
Birnbaum S, Sharshar T, Eymard B, Theaudin M, Portero P, Hogrel JY. Marathons and myasthenia gravis: a case report. BMC Neurol. 2018;18(1):145.
Birnbaum S, Bachasson D, Sharshar T, Porcher R, Hogrel JY, Portero P. Free-living physical activity and sedentary behaviour in autoimmune myasthenia gravis: A cross-sectional study. J. Neuromuscu.l Dis. 2021;8(4):689-697.
O'Connor L, Westerberg E, Punga AR. Pattern of habitual physical exercise in myasthenia gravis patients. J. Neuromuscul. Dis. 2019;6(1):85-91.
Andersen LK, Vissing J. Habitual physical activity in patients with myasthenia gravis assessed by accelerometry and questionnaire. J. Neuromuscul. Dis. 2022;9(1):161-169.
Patterson R, McNamara E, Tainio M, et al. Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis. European journal of epidemiology. 2018;33(9):811-829.
Ekelund U, Tarp J, Fagerland MW, et al. Joint associations of accelero-meter measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals. British journal of sports medicine. 2020;54(24):1499-1506.
Lee IM, Shiroma EJ, Lobelo F, et al. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012;380(9838):219-229.
Voet NBM. Exercise in neuromuscular disorders: a promising intervention. Acta myologica: myopathies and cardiomyopathies: official journal of the Mediterranean Society of Myology. 2019;38(4):207-214.
Birnbaum S, Sharshar T, Ropers J, Portero P, Hogrel J. Neuromuscular fatigue in autoimmune myasthenia gravis: a cross-sectional study. Neurophysiol. Clin. 2023;53(4).
Gilhus NE. Physical training and exercise in myasthenia gravis. Neuromuscul. Disord. 2021;31(3):169-173.
O'Connor L, Westerberg E, Punga AR. Myasthenia gravis and physical exercise: A novel paradigm. Frontiers in neurology. 2020;11:675.
Naumes J, Hafer Macko C, Foidel S. Exercise and myasthenia gravis: A review of the literature to promote safety, engagement, and functioning. International Journal of Neurorehabilitation. 2016.
Anziska Y, Inan S. Exercise in neuromuscular disease. Seminars in neurology. 2014;34(5):542-556.
Birnbaum S, Porcher R, Portero P, et al. Home-based exercise in autoimmune myasthenia gravis: A randomized controlled trial. Neuromuscul Disord. 2021;31(8):726-735.
Misra UK, Kalita J, Singh VK, Kapoor A, Tripathi A, Mishra P. Rest or 30-min walk as exercise intervention (RESTOREX) in myasthenia gravis: A randomized controlled trial. Eur. Neurol. 2021;84(3):168-174.
Chang CC, Chen YK, Chiu HC, Yeh JH. Changes in physical fitness and body composition associated with physical exercise in patients with myasthenia gravis: A longitudinal prospective study. J. Clin. Med. 2021;10(17).
Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985;100(2):126-131.
Abresch RT, Carter GT, Han JJ, McDonald CM. Exercise in neuromuscular diseases. Physical medicine and rehabilitation clinics of North America. 2012;23(3):653-673.
Farrugia ME, Di Marco M, Kersel D, Carmichael C. A physical and psychological approach to managing fatigue in myasthenia gravis: A pilot study. J. Neuromuscul. Dis. 2018;5(3):373-385.
Lohi EL, Lindberg C, Andersen O. Physical training effects in myasthenia gravis. Archives of physical medicine and rehabilitation. 1993;74(11):1178-1180.
Rahbek MA, Mikkelsen EE, Overgaard K, Vinge L, Andersen H, Dalgas U. Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training. Muscle & nerve. 2017;56(4):700-709.
Westerberg E, Molin CJ, Sporndly Nees S, Widenfalk J, Punga AR. The impact of physical exercise on neuromuscular function in myasthenia gravis patients: A single-subject design study. Medicine. 2018;97(31):e11510.
Westerberg E, Molin CJ, Lindblad I, Emtner M, Punga AR. Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance-based measures: A pilot study. Muscle & nerve. 2017;56(2):207-214.
Hafer-Macko C, Macko R, Naumes J. Impact of exercise on function in the myasthenia gravis population. Muscle and nerve. 2016;54(3): 646.
Wong SH, Nitz JC, Williams K, Brauer SG. Effects of balance strategy training in myasthenia gravis: a case study series. Muscle & nerve. 2014;49(5):654-660.
Scheer BV, Valero-Burgos E, Costa R. Myasthenia gravis and endurance exercise. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. 2012;91(8):725-727.
Stout JR, Eckerson JM, May E, Coulter C, Bradley-Popovich GE. Effects of resistance exercise and creatine supplementation on myasthenia gravis: a case study. Medicine and science in sports and exercise. 2001;33(6):869-872.
Leddy JJ, Chutkow JG. Myasthenia gravis in a collegiate football player. Medicine and science in sports and exercise. 2000;32(12):1975-1979.
Pilutti LA, Platta ME, Motl RW, Latimer-Cheung AE. The safety of exercise training in multiple sclerosis: a systematic review. Journal of the neurological sciences. 2014;343(1-2):3-7.
Barnett C, Herbelin L, Dimachkie MM, Barohn RJ. Measuring clinical treatment response in myasthenia gravis. Neurologic clinics. 2018;36(2):339-353.
Lindheimer JB, Szabo A, Raglin JS, Beedie C. Advancing the understanding of placebo effects in psychological outcomes of exercise: Lessons learned and future directions. Eur. J. Sport Sci. 2020;20(3):326-337.
Vanier A, Oort FJ, McClimans L, et al. Response shift in patient-reported outcomes: definition, theory, and a revised model. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2021;30(12):3309-3322.
Hansford HJ, Wewege MA, Cashin AG, et al. If exercise is medicine, why don't we know the dose? An overview of systematic reviews assessing reporting quality of exercise interventions in health and disease. British journal of sports medicine. 2022;56(12):692-700.
Lai B, Kim Y, Wilroy J, Bickel CS, Rimmer JH, Motl RW. Sustainability of exercise intervention outcomes among people with disabilities: a secondary review. Disability and rehabilitation. 2019;41(13):1584-1595.
WHO guidelines on physical activity and sedentary behaviour. [press release]. Geneva:: World Health Organization; , 2020.
Alsop T, Williams K, Gomersall S. Physical activity and sedentary behaviour in people with myasthenia gravis: A cross-sectional study. J. Neuromuscul. Dis. 2022;9(1):137-146.
Davidson L, Hale LA. Exercise prescription in the physiotherapeutic management of myasthenia gravis: a case report. New Zealand Journal of Physiotherapy. 2005;33(1):13-18.
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Copyright (c) 2023 Simone Birnbaum PhD BPhty, Tarek Sharshar Pr, Jean-Yves Hogrel PhD
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