Diagnostic and treatment challenges in MRI-negative myelitis associated with MOG antibody: A case report and literature review.
DOI:
https://doi.org/10.17161/rrnmf.v6i1.21721Keywords:
Myelin oligodendrocyte glycoprotein, Neuromyelitis optica spectrum disorder, Longitudinal extensive transverse myelitis, acute transverse myelitisAbstract
Background:
MRI negative cases of anti-MOG-seropositive longitudinally extensive transverse myelitis (LETM), optic neuritis and encephalitis have been reported in the literature. Negative MRI can lead to diagnostic uncertainties and treatment delay.
Objectives:
We report a case of a patient with LETM with negative spinal MRI who tested positive for serum MOG antibody and showed continuous improvement with immunotherapy.
Conclusion:
Negative spinal cord MRI in patients with clinical presentation of LETM or transverse myelitis should not preclude investigation of MOG Antibody associated disease and initiation of early empirical immunotherapy.
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Copyright (c) 2025 Dr. Gloria Ortiz-Guerrero, Dr. Daniel Mafla, Dr. Carley Carter, Dr. Arpan Patel
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