Anti-neuronal Autoantibody Type 1 (Anti-Hu) Paraneoplastic Neurologic Syndrome Causing Jaw Dystonia
DOI:
https://doi.org/10.17161/rrnmf.v5i2.21976Keywords:
paraneoplastic syndrome, dystoniaAbstract
Anti-neuronal nuclear autoantibody type1 (ANNA-1), or anti-Hu, paraneoplastic neurologic syndrome (PNS) classically manifests with sensory neuronopathy and encephalomyelitis. We describe a rare case of anti-ANNA-1 PNS presenting with marked jaw dystonia and cognitive impairment. Her symptoms complicated the evaluation for an underlying malignancy and severely impacted her functional status due to malnutrition and increased disability. Symptomatic management focused on reducing the severity of jaw dystonia, which improved her overall function and allowed for treatment of her underlying malignancy.
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Copyright (c) 2024 Joseph Conway, Katherine Havard, Justin Abbatemarco, Albert Aboseif, Emily Maly, Amy Kunchok, Payal Soni, James Liao
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
