Amyloid Myopathy as an Inclusion Body Myositis Mimic

Authors

  • Anai C. Hamasaki, M.D. Department of Neurology, University of Oklahoma Health Sciences Center,Oklahoma City, OK
  • Ryan D. Jacobson, M.D. Department of Neurology, Loyola University Chicago, Chicago, IL
  • Barbara J. Distad, M.D. Department of Neurology, University of Washington, Seattle, WA
  • Michael D. Weiss, M.D. Department of Neurology, University of Washington, Seattle, WA
  • Jeffrey M. Statland, M.D. Department of Neurology, University of Kansas Medical Center, Kansas City, KS
  • Omar Jawdat, M.D. Department of Neurology, University of Kansas Medical Center, Kansas City, KS
  • Melanie D. Glenn, M.D. Department of Neurology, University of Kansas Medical Center, Kansas City, KS
  • Laura Herbelin, B.S. Department of Neurology, University of Kansas Medical Center, Kansas City, KS
  • Richard J. Barohn, M.D. University of Missouri, Columbia, MO
  • Mamatha Pasnoor, M.D. Department of Neurology, University of Kansas Medical Center, Kansas City, KS
  • Gary W. Gallagher, M.D. Department of Neurology, University of Michigan, Ann Arbor, MI
  • Sandra I. Camelo-Piragua, M.D. Department of Pathology, University of Michigan, Ann Arbor, MI
  • Andrew J. Heim, C.C.R.P. Department of Neurology, University of Kansas Medical Center, Kansas City, KS
  • Mazen M. Dimachkie, M.D. Department of Neurology, University of Kansas Medical Center, Kansas City, KS

DOI:

https://doi.org/10.17161/rrnmf.v1i4.13699

Abstract

Introduction: Amyloid myopathy is a rare presentation of systemic amyloidosis. Amyloid myopathy can be initially misdiagnosed as sporadic inclusion body myositis (IBM).

Methods: We report 4 cases of amyloid myopathy clinically mimicking inclusion body myositis and initially thought to be phenotypically IBM by neuromuscular experts.

Results: Case 1 is an 81-year-old woman who presented with distal arm and proximal leg asymmetric weakness (myopathy pattern 4). Case 2 is a 76-year-old man with primary systemic amyloidosis who presented with myopathy pattern 4 and progressive dysphagia for four years. Case 3 is an 82-year-old man with progressive myopathy pattern 4 weakness and swallowing difficulty. Case 4 is a 62-year-old man with progressive bilateral finger flexor weakness. Muscle biopsies in all 4 cases showed perivascular amyloid deposits

Discussion: Amyloid myopathy may be clinically indistinguishable from IBM. Muscle biopsy is of critical importance in the evaluation of patients suspected to have IBM.

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Published

2020-09-21

Issue

Section

Clinic and Case Reports

How to Cite

Hamasaki, A., Jacobson, R., Distad, B., Weiss, M., Statland, J., Jawdat, O., Glenn, M., Herbelin, L., Barohn, R. J., Pasnoor, M., Gallagher, G., Camelo-Piragua, S., Heim, A., & Dimachkie, M. (2020). Amyloid Myopathy as an Inclusion Body Myositis Mimic. RRNMF Neuromuscular Journal, 1(4), 28-32. https://doi.org/10.17161/rrnmf.v1i4.13699