Amyloid Myopathy as an Inclusion Body Myositis Mimic


  • Andrew Heim University of Kansas Medical Center
  • Anai Hamasaki Oklahoma University Health Sciences Center
  • Mazen Dimachkie University of Kansas Medical Center
  • Mamatha Pasnoor University of Kansas Medical Center
  • Omar Jawdat University of Kansas Medical Center
  • Jeffrey Statland University of Kansas Medical Center
  • Ryan Jacobson
  • Barbara Distad
  • Michael Weiss
  • Melanie Glenn
  • Gary Gallagher
  • Sandra Camelo-Piragua
  • Laura Herbelin



Introduction: Amyloid myopathy is a rare presentation of systemic amyloidosis. Amyloid myopathy can be initially misdiagnosed as sporadic inclusion body myositis (IBM).

Methods: We report 4 cases of amyloid myopathy clinically mimicking inclusion body myositis and initially thought to be phenotypically IBM by neuromuscular experts.

Results: Case 1 is an 81-year-old woman who presented with distal arm and proximal leg asymmetric weakness (myopathy pattern 4). Case 2 is a 76-year-old man with primary systemic amyloidosis who presented with myopathy pattern 4 and progressive dysphagia for four years. Case 3 is an 82-year-old man with progressive myopathy pattern 4 weakness and swallowing difficulty. Case 4 is a 62-year-old man with progressive bilateral finger flexor weakness. Muscle biopsies in all 4 cases showed perivascular amyloid deposits

Discussion: Amyloid myopathy may be clinically indistinguishable from IBM. Muscle biopsy is of critical importance in the evaluation of patients suspected to have IBM.


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How to Cite

Heim, A., Hamasaki, A., Dimachkie, M., Pasnoor, M., Jawdat, O., Statland, J., Jacobson, R., Distad, B., Weiss, M., Glenn, M., Gallagher, G., Camelo-Piragua, S., & Herbelin, L. (2020). Amyloid Myopathy as an Inclusion Body Myositis Mimic. RRNMF Neuromuscular Journal, 1(4), 28-32.



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