A Second Case of Treatment-resistant CIDP in an IgG Tubulin Autoantibody Positive Patient


  • Alaina Giacobbe MD University of Florida
  • Tawfiq Al-Lahham MD UPMC
  • Ajitesh Ojha MD UPMC
  • Sasha Zivkovic MD UPMC




CIDP, IgG tubulin autoantibodies, rituximab, demyelinating neuropathy


Download data is not yet available.


Giacobbe A, Patel M, Heller S, Chuquilin M. Treatment-resistant CIDP in an IgG Tubulin Autoantibody Positive Patient: case report and review of the literature. RRNMF Neuromuscular Journal. 2020 Nov 30;1(5):20-4.

Connolly AM, Pestronk A. Anti-tubulin autoantibodies in acquired demyelinating polyneuropathies. Journal of Infectious Diseases. 1997 Dec 1;176(Supplement_2):S157-9. DOI: 10.1086/513801 PMID: 9396702

Connolly AM, Pestronk A, Trotter JL, Feldman EL, Cornblath DR, Olney RK. High-titer selective serum anti-tubulin antibodies in chronic inflammatory demyelinating polyneuropathy. Neurology 1993;43(3, Part 1):557-557. doi:10.1212/wnl.43.3_part_1.557. PMID 8451001

Schaik IN, Vermeulen M, Doom PA, Brand A. Anti-tubulin antibodies have no diagnostic value in patients with chronic inflammatory demyelinating polyneuropathy. Journal of Neurology 1995;242(9):599-603. doi:10.1007/bf00868814. PMID 8551323

Manfredini E, Nobile-Orazio E, Allaria S, Scarlato G. Anti-alpha- and beta-tubulin IgM antibodies in dysimmune neuropathies. Journal of the Neurological Sciences. 1995;133(1-2):79-84. doi:10.1016/0022-510x(95)00149-v. PMID 8583236

Van den Bergh PY, van Doorn PA, Hadden RD, Avau B, Vankrunkelsven P, Allen JA, et al. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision. Journal of the Peripheral Nervous System. 2021 Sep;26(3):242-68. DOI: 10.1111/jns.12455 PMID: 34085743

Shibuya K, Tsuneyama A, Misawa S, Suichi T, Suzuki Y, Kojima Y, et al. Cranial nerve involvement in typical and atypical chronic inflammatory demyelinating polyneuropathies. European Journal of Neurology. 2020 Dec;27(12):2658-61. DOI: 10.1111/ene.14497. PMID: 32876980

Živković SA, Peltier AC, Iacob T, Lacomis D. Chronic inflammatory demyelinating polyneuropathy and ventilatory failure: report of seven new cases and review of the literature. Acta Neurologica Scandinavica. 2011 Jul;124(1):59-63. DOI: 10.1111/j.1600-0404.2010.01431.x. PMID: 21649602

Dionne A, Nicolle MW, Hahn AF. Clinical and electrophysiological parameters distinguishing acute-onset chronic inflammatory demyelinating polyneuropathy from acute inflammatory demyelinating polyneuropathy. Muscle Nerve 2010;41:202–7. DOI: 10.1002/mus.21480. PMID: 19882646

Macia F, Le Masson G, Rouanet-Larriviere M, Habonimana D, Ferrer X, Marthan R, et al. A prospective evaluation of phrenic nerve conduction in multifocal motor neuropathy and chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 2003;28:319–23. DOI: 10.1002/mus.10430. PMID: 12929191

Cocito D, Ciaramitaro P, Rota E, Isoardo G, Cannizzo S, Poglio F, et al. Subclinical electrophysiological alterations of phrenic nerve in chronic inflammatory demyelinating polyneuropathy. J Neurol 2005;252:916–20. DOI: 10.1007/s00415-005-0780-5. PMID: 15772737

Netherton SJ, Owen CJ, Zochodne DW. Monophasic CIDP Associated with Autoimmune Hemolytic Anemia. Canadian Journal of Neurological Sciences. 2014 Mar;41(2):290-2. DOI: 10.1017/s0317167100016772. PMID: 24534050

Kamesaki T, Oyamada T, Omine M, Ozawa K, Kajii E. Cut-off value of red-blood-cell-bound IgG for the diagnosis of Coombs-negative autoimmune hemolytic anemia. Am J Hematol. 2009 Feb;84(2):98-101. doi: 10.1002/ajh.21336. PMID: 19105232.

Rousset B, Bernier-Valentin F, Poncet C, Orgiazzi J, Madec AM, Monier JC, et al. Anti-tubulin antibodies in autoimmune thyroid disorders. Clin Exp Immunol. 1983 May;52(2):325-32. PMID: 6688044; PMCID: PMC1535862.

Rodríguez Y, Vatti N, Ramírez-Santana C, Chang C, Mancera-Páez O, Gershwin ME, et al. Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease. Journal of autoimmunity. 2019 Aug 1;102:8-37. DOI: 10.1016/j.jaut.2019.04.021. PMID: 31072742

Muley SA, Kelkar P, Parry GJ. Treatment of Chronic Inflammatory Demyelinating Polyneuropathy With Pulsed Oral Steroids. Arch Neurol. 2008;65(11):1460–1464. doi:10.1001/archneur.65.11.1460. PMID: 19001164.

Querol L, Siles AM, Alba-Rovira R, Jauregui A, Devaux J, Faivre-Sarrailh C, et al. Antibodies against peripheral nerve antigens in chronic inflammatory demyelinating polyradiculoneuropathy. Sci Rep. 2017; 7(1):14411. DOI: 10.1038/s41598-017-14853-4. PMID: 29089585




How to Cite

Giacobbe, A., Al-Lahham, T., Ojha, A., & Zivkovic, S. (2022). A Second Case of Treatment-resistant CIDP in an IgG Tubulin Autoantibody Positive Patient. RRNMF Neuromuscular Journal, 3(3), 21–24. https://doi.org/10.17161/rrnmf.v3i3.17691



Clinic Stuff (Case Reports)